i wouldnt break it at the door ways unless you have explained to the customer first why you had to,it may fall ok,
best thing i do is spend a 1/2 day setting out, center the main entrance and run a few lines through to the other rooms,dry lay some tiles if you feel you can visualise it better ( i do), see how the cuts fall then explain the solutions, i do put a mastic joint on every door way usualy between 5 & 10mm the customer will want the smaller joint they always do

, if theres underfloor heating ?...heated screeds i always use, (PCI Pecilastic mat and nanolite)